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In the latest examine, we reported the identification along with the characterization of a new atypical opioid receptor with unique unfavorable regulatory Houses to opioid peptides.1 Our results showed that ACKR3/CXCR7, hitherto referred to as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is likewise a wide-spectrum scavenger for